Satisfaction in sex is very important for leading a successful intimate life with your partner. But, bodily dysfunctions in both, men and women can lead to discontentment and disaffection for either or both of the partners. 

Cenforce is a prescription drug used by men to treat Erectile Dysfunction, commonly known as impotence. This particular drug is composed of Sildenafil Nitrate which belongs to the Phosphodiesterase (PDE) 5 inhibitors class of drugs. For the drug to work successfully, sexual stimulation is necessary. 

Cenforce is easily available on the market in the form of oral pills, in weights ranging from 25mg up to 200mg.  


Grapefruit and grapefruit juice, in general, are healthy to consume. Taking them alone can provide the body with enough Vitamin C, dietary fiber, potassium and various other nutrients considered good for the heart of a human being. But, what the matter of concern is that grapefruit juice, when combined with some of the medications, can prove to be destructive. 

Grapefruit Juice (GFJ) contains hundreds of chemicals but the chemical that worries the doctors is furanocoumarin. Furanocoumarins are mechanism-based potent inhibitors of CYP3A4 (CYP3A4  is an enzyme found in the body, in the liver and intestine). These chemicals do not directly interact with the pills you take, but tie up to the CYP3A4 enzyme. This results in reduction of absorption of certain medications. 

Various scientific studies have found that Grapefruit juice is responsible for metabolizing more than 65% of all drugs, which is a matter of concern. 


Finding its place in the list of medications that have a serious interaction with Grapefruit juice, Cenforce (Sildenafil) is also metabolized by CYP3A4 found in Grapefruit Juice. 

A study found that taking approximately 250 ml of grapefruit juice one hour before intercourse increases the bioavailability (the ability of a substance to be used by the body after absorption) of sildenafil by 23% but at the same time is capable of delaying the drug’s absorption

Studies conducted in Germany in the US and published in 2001 and 2002 found that grapefruit tend to raise the peak concentrations of sildenafil in plasma. 

Consuming Grapefruit Juice whilst taking Cenforce can result in an increase in the level of the drug in your blood. This can make the consumer vulnerable to side effects, such as headaches, threatening fluctuations in blood pressure etc. . GFJ may result in changes to the absorption of Cenforce for up to 24 hours. 

Taking Cenforce 100 at the same time or within the same day of consuming Grapefruit Juice can have the same or similar effect as when taking the drug with a nitrate medicine i.e. severe drop in Blood Pressure. So, if you have a feeling of nausea, dizziness, numbness or tingling in the chest, jaw, arm, or neck, you should seek immediate medical attention. 

The very purpose of taking Cenforce is to boost sexual pleasure and intimacy. The same can be taken away by combining the drug with GFJ as we have seen above how both of these interact with each other. It can make the man uncomfortable and under-confident and can cause disturbances in the private life of the partners.

Thus, it is advised to avoid taking grapefruit with sildenafil (Cenforce) and to follow your healthcare provider’s advice. 


It can be concluded that taking grapefruit juice with Cenforce can have severe outcomes and regularly combining the consumption of both can reach a more dangerous level leading to complications in the body of the consumer. If you are regularly taking Cenforce for treatment of ED, you should consider avoiding the regular consumption of large amounts and grapefruit juice as well as grapefruit as it can raise the levels of sildenafil in your body and delay the time it takes for the medication to work.

By AESir